Dr. Soo-Chen Cheng

Molecular Mechanism of the pre-mRNA splicing reaction

The 29th Academician of Life Sciences

Old News of the Academian

Education

Senior High School- Taipei First Girls High School

1977- Dept. Chemistry, Natl. Taiwan Univ.

1983- Dept. Biochemistry., Duke Univ., USA

 

Professional Experience

1983-1984 Lab. Mol. Virol., NIH, USA

1984-1988 Div. Biol., Caltech, USA

1988-1994 Associate Research Fellow, IMB

1994-2003 Research Fellow, IMB

2003-2013 Distinguished Research Fellow, IMB

2013 Feb- present Director & Distinguished Research Fellow, IMB

 

Awards and Honors:

- Outstanding Award, National Science Council (1994, 2010)

- Frontier Science Research Award, National Science Council (1999-2004, 2005-10)

- Hsu Yu-Ziang Award, Papers of Science and Technology (2003)

- Ho Chin-Tuei Outstanding Honorary Award in Basic Science (2005)

- Academia Sinica Investigator Award (2005-09, 2010-14)

- Academic Award, Ministry of Education (2007)

- Academic Summit Research Award, National Science Council (2009-14)

- TWAS Prize in Biology (2010)

- Elected Member, The World Academy of Sciences (TWAS)(2013)

Learning and Exploring

  Dr. Soo- Chen Cheng studied chemistry as major in the university, and joined Dr. Tong- Bi Lo’s research program in the fourth year. This was the time Dr. Cheng became interested in the area of biochemistry, which she wanted to devote more efforts into. Dr. Cheng decided to study more about it aboard, and was expecting to gain more new life experiences.

With courage that comes from inexperience, Dr. Cheng applied to Duke University in America where there were only a few Chinese students to study biochemistry. She was expecting for different life experience, but she did struggle a lot during her first year. There were problems such as adjusting different customs and language, pressure from school and subjects, and the unfamiliarity of hostile life. After a year, Dr. Cheng moved away from the dormitory and began her research thesis in the laboratory. During the time in the laboratory, Dr. Cheng found it inspiring and satisfying about learning and exploring, which made her determined to keep on researching as her future career.

 

The Enlightens

   Besides Dr. Tong- Bi Lo, Professor 摩德理查is one of the scholars that have influenced Dr. Cheng the most. He is an expert in biochemistry which specializes in the interaction of nucleic acid and proteins, and the identification of deoxyribonucleic acid (DNA) by restriction enzyme.

   Professor 摩德理查 is a rigorous person when doing an experiment. Dr. Cheng had once spent three months for doing a simple experiment to be approved by the professor. This builds up the strict and cautious attitude of Dr. Cheng in researching.

 Dr. Cheng specializes in the molecular mechanism of the pre-mRNA splicing reaction. “Before human body makes protein, RNA is produced first. After the combination of RNA there are still many extra sequences to be removed. This is known as splicing. If the splicing does not work well, the genotype will be different and affect the development of the cells, which might leads to mutation.”

Dr. Cheng joined Professor Albertson for master research in the California Institute of Technology. Professor Albertson is the pioneer of molecular mechanism of the pre-mRNA splicing reaction. Here, Dr. Cheng has learned to compete, corporate, and progress at the same time with other outstanding scientists.

 

Passing down the Values

   After returning to Taiwan in 1988, Dr. Cheng continued with her research in Institute of Molecular Biology, Academia Sinica, Taiwan. With her experiences and rigorousness, the research has developed well throughout the years. Dr. Cheng often reminds the students “to devote full efforts once you decide to participate”, which passes down the right attitude and principles of researching. She believes that the most satisfaction for her is to witness the students progressing and fulfilling the goals.

Travelling around to ease up

 Dr. Cheng has been a traveler since she was a teenager. She has been to many countries and places including United States, Germany, Austria, Switzerland, Italy, France, etc. However she has always dreamed to visit a place with large fields of grasslands. As the amount of work increases, the hardworking Dr. Cheng who always accomplishes tasks with efficiency has had a busy life. Her best solution for the pressure in life is to travel around and be surrounded by nature. She has visited several countries in America and Europe, as well as northern Xinjiang.

This was where Dr. Cheng found her dreaming heaven, a whole flat of green field spreading out far beyond the horizon. She loves the residents’ natural casual way of living. Whenever there are difficulties during the research, the best resolution is to travel around and relax instead of getting stuck in the moment. You can only move forward with a delightful heart.

 It is easy to feel Dr. Cheng’s excitement when she talks about the experiences from her 16 days journey to northern Xinjiang in China. “The wooden houses on the fields, the kids riding horses, and the magnificent view of valley are amazingly beautiful as these were landscape in paint.” She entered the tent and saw the furniture of Kazakhs. The transparent pink curtain and table cloth gave the impression of romantic, warm, and fragrant. The friendly hosts gave Dr. Cheng a cup of fresh koumiss to show their welcome. Dr. Cheng has gained different experiences from the journey to the northern Xinjiang. She is expecting eagerly for another adventure to the desert of southern Xinjiang.

Not only being as a scientist and an academician, but also the mother of two children. Dr. Cheng strongly believes the importance of time management and efficiency. For instance, she will complete all the trifling business every time she leaves the laboratory. Also, the bill will be automatically transferred in accounts.

For Dr. Cheng, the most interesting part within the research is to resolve the problem by designing sets of experiments. Although the result might be different from what you expected, the new discoveries that you found out accidentally are even more exiting. “Science is full of surprises!” she indicates at the same time as reminding the youths to relax and ease up the tension when there is a problem. Going for a short walk, discussing with classmates can be delightful things to reduce your pressure, which will avail the studying and learning.

 

(Summarized by Maisie Chen)

2012. 11. 05 Liberty Times

 

“Once you decide to do an experiment, you must devote all the effort into it. It’s not only about the experiments, but everything in your life must be done as perfect as it could be. The only way to achieve this is by doing your job with dedication.”

- Dr. Soo- Chen Cheng